Section I. Clinical, Laboratory, and Radiological Features Epidemiology
1. Clinical Features and Differential Diagnosis 2. Prognosis and Clinical Course 3. Clinical and Laboratory Measures of Disease 4. Diagnostic Autoantibodies 5. Plain Radiography 6. Measurement of Radiological Outcomes 7. Ultrasonography and MRI
Section II. Section III. Pathogenesis
8. Genetics 9. Overview of Pathogenesis 10. Synovial Tissue Pathology 11. Cytokines 12. Leukocyte Recruitment and Angiogenesis 13. Neutrophils and Inflammation 14. Cellular and Humoral Immunity in Synovitis 15. Autoimmunity 16. Complement and Innate Immunity 17. Synoviocyte Proliferation 18. Bone and Cartilage Destruction 19. The Role of T Cells 20. Animal Models
Section IV. Therapy
21. Approach to Therapy 22. NSAIDS and Analgesics 23. Corticosteroids (Systemic and Intra-articular) 24. Methotrexate and Azathioprine 25. Sulfasalazine 26. Gold Compounds, Hydroxychloroquine, D-Penicilamine, Bucillamine, and Azathioprine 27. Minocycline 28. Cyclosporine 29. Leflunomide 30. Infliximab and Adalimumab 31. Etanercept 32. Anakinra 33. Staphylococcal Protein A 34. Combination DMARD Therapy 35. Treatment of Early Disease
Section V. Non-Pharmacologic Therapy
36. Behavioral Therapy 37. Occupational Therapy 38. Surgery
-Total Joint Arthroplasty
-Hand and Wrist Surgery
-Foot and Ankle Surgery
-Cervical Spine Surgery
39. Special Management Issues
-Treatment of Extra-Articular Disease
-Osteoporosis
-Depression
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